According to the records of relevant historical materials and the research results of relevant scholars, the author divides Li Shizhen and his Compendium of Materia Medica into four parts: Ming Dynasty 1518-1644, Qing Dynasty 1644-1911, Republic of China 1912-1948, From 1949 to 2018 after the founding of the Peoples Republic of China, Li Shizhens life and the dissemination and influence of Compendium of Materia Medica at home and abroad for 500 years were comprehensively sorted out, and detailed collection records were collected by dynasty and year, which fully demonstrated Li Shizhens growth History and the compiling and publishing process of Compendium of Materia Medica, and the major events of the dissemination and influence of Compendium of Materia Medica at home and abroad for more than 420 years after its publication. It also contains the research on Li Shizhens historical facts. This book is of great historical value, and its publication will play a positive role in promoting the research of Li Shizhens Compendium of Materia Medica, and it is also our gift to the 500th anniversary of Li Shizhens birth.